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We are pleased to announce the availability for July/2018 of the book Theoretical and Applied Aspects of Systems Biology, published in the Springer Computational Biology Series.

This book gathers contributions from the speakers of the 2017 International Course on Theoretical and Applied Aspects of Systems Biology, as well as invited chapters. The book web site URL is:

The table of contents is below:


Preface. Fabricio Alves Barbosa da Silva, Nicolas Carels and Floriano Paes Silva-Jr

Foreword.  Jonathan Karr


PART I – Fundamentals

1 - Bio-modeling using Petri nets: A computational approach. Rafael Viana de Carvalho, Fons J. Verbeek, Clarimar J. Coelho

2 - Modeling Gene Transcriptional Regulation: A Primer. Marcelo Trindade dos Santos, Ana Paula Nascimento, Fernando Medeiros Filho, Fabrício Alves Barbosa da Silva

3 – Cell Reprogramming. Domenico Sgariglia, Alessandra Jordano Conforte, Luis Alfredo Vidal de Carvalho, Nicolas Carels, Fabricio Alves Barbosa da Silva

4 - Metabolic models: from DNA to physiology (and back). Marcio Argollo de Menezes

5 - Analysis Methods for Shotgun Metagenomics. Stephen Woloszynek, Zhengqiao Zhao, Gregory Ditzler, Jacob R. Price, Erin R. Reichenberger, Yemin Lan, Jian Chen, Joshua Earl, Saeed Keshani Langroodi, Garth Ehrlich, Gail Rosen

6 – ANOCVA: a non-parametric statistical test to compare clustering structures. Alexandre Galvão Patriota, Maciel Calebe Vidal, Davi Augusto Caetano de Jesus, and André Fujita


PART II - Applied Systems Biology

7 - Modeling of cellular systems: application in stem cell research and computational disease modeling. Muhammad Ali, Antonio del Sol

8 - Using Thermodynamic Functions as an Organizing Principle in Cancer Biology. Edward Rietman and Jack A. Tuszynski

9 - Systems Immunology. Melissa Lever, Thiago C. Hirata, Pedro ST Russo, Helder I Nakaya

10 - The challenge of translating system biology into targeted therapy of cancer. Alessandra Jordano Conforte, Milena Magalhães, Tatiana Martins Tilli, Fabricio Alves Barbosa da Silva, Nicolas Carels

11 - Computational modeling of multidrug-resistant bacteria.  Fabricio Alves Barbosa da Silva, Fernando Medeiros Filho, Thiago Merigueti, Thiago Giannini, Rafaela Brum, Laura Machado de Faria, Ana Paula Nascimento, Kele Belloze, Floriano Paes Silva-Jr, Rodolpho Albano, Marcelo Trindade dos Santos, Maria Clicia Castro, Márcio Argollo and Ana Paula D’A. Carvalho-Assef

12 - System biology to access target relevance in the research and development of molecular inhibitors. Larissa Catharina Costa, Nicolas Carels, Marcio Argollo de Menezes

13 - Mathematical-Computational Modeling in Behavior’s Study of Repetitive Discharge Neuronal Circuits. Vanessa Rodrigues, Camila Kalil, Maria Clicia Stelling de Castro, Dilson Silva, Celia Martins Cortez