Book Cover2


We are pleased to announce the availability of the book Networks in Systems Biology: Applications for Disease Modeling, published in the Springer Computational Biology Series (sponsored by the International Society for Computational Biology - ISCB):


This book gathers contributions from the speakers of the 2019 International Course on Theoretical and Applied Aspects of Systems Biology, as well as invited chapters.

The table of contents is below:


Preface. Fabricio Alves Barbosa da Silva, Nicolas Carels and Marcelo Trindade dos Santos e Francisco José Pereira Lopes

Foreword.  Paulo Bisch


Part I - Biological Networks and Methods in Systems Biology


1 - Network Medicine: Methods and Applications. Italo F. do Valle, Helder I Nakaya

2 - Computational tools to compare biological networksVinicius Jardim Carvalho and André Fujita

3 - Functional Gene Networks and their Applications. Hong-Dong Li, Yuanfang Guan

4 - A Review of Artificial Neural Networks for the Prediction of Essential Proteins. Kele Belloze, Luciana Campos, Ribamar Matias, Ivair Luques, and Eduardo Bezerra

5 - Transcriptograms: a genome wide gene expression analysis method. Rita M.C. de Almeida, Lars L.S. de Souza , Diego Morais, and Rodrigo J.S. Dalmolin

6 - A Tutorial on Sobols’ Global Sensitivity Analysis Applied to Biological Models. Michel Tosin, Adriano M. A. Côrtes, and Americo Cunha Jr  

7 - Reaction network models as a tool to study gene regulation and cell signaling in development and diseases. Francisco José Pereira Lopes, Claudio Daniel Tenório de Barros, Josué Xavier de Carvalho, Fernando de Magalhães Coutinho Vieira, Cristiano N. Costa.


Part II - Disease and Pathogen Modeling


8 - Challenges for the optimization of drug therapy in the treatment of cancerNicolas Carels, Alessandra Conforte, Carlyle Lima, Fabricio Alves Barbosa da Silva

9 - Opportunities and challenges provided by Boolean modelling of cancer signalling pathways. Petronela Buiga, Jean-Marc Schwartz

10 - Integrating Omics Data to Prioritize Target Genes in Pathogenic Bacteria. Marisa Fabiana Nicolás, Maiana de Oliveira Cerqueira e Costa, Pablo Ivan P. Ramos, Marcelo Trindade dos Santos, Ernesto Perez-Rueda, Marcelo A. Marti, Dario Fernandez Do Porto, Adrian G. Turjanski 

11 - Modelling oxidative stress pathways. Harry Beaven & Ioly Kotta-Loizou

12 - Computational Modeling in Virus Infections and Virtual Screening, Docking and Molecular Dynamics in Drug Design. Rachel Siqueira de Queiroz Simões, Mariana Simões Ferreira,  Nathalia Dumas de Paula, Thamires Rocco Machado, Pedro Geraldo Pascutti

13 - Cellular Regulatory Network Modeling Applied to Breast Cancer. Luiz Henrique Oliveira Ferreira , Maria Clicia Stelling de Castro , Alessandra Jordano Conforte, Nicolas Carels, Fabrício Alves Barbosa da Silva